Cytochrome c is important in apoptosis of labial glands in primary Sjogren's syndrome
نویسندگان
چکیده
منابع مشابه
Primary Sjogrens Syndrome in a Child
Sjögren syndrome is uncommon in children and occurs most often in association with autoimmune diseases (secondary Sjögren syndrome). We describe the clinical and biological features of a 7-year-old girl with primary Sjögren syndrome revealed by recurrent parotiditis. CASE REPORT A 7-year-old girl was referred for investigation of multiple episodes of parotid swelling since age 4 years, withou...
متن کاملSelective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients
The aim of this study was to investigate the initiation and progression of autoimmune damage in the lesions of labial salivary glands (LSGs) from primary Sjögren's syndrome (SS) patients by examining the selective localization of T helper (Th) subsets such as Th1, Th2, Th17 regulatory T cells (T(regs)) and follicular T helper cells (Tfh). The expression of cytokines and transcription factors as...
متن کامل3431 Conjunctiva immunopathology in primary sjogrens syndrome (1° S.S.)
Aim: To evaluate the histological changes and immune response of conjuctiva in patients (pts) with lo S.S. Materials and Methods: We studied conjunctiial biopsies from 15 pts with I0 S.S. and 2 normal controls using 1) paraflfn section screening for the quality of conjunctival epithelium (CE), the number of goblet cells (GC) and the degree of inflammation, 2) Mo-abs and Pabs to: Tlymphocytes, T...
متن کاملMR imaging of labial glands.
BACKGROUND AND PURPOSE The labial salivary gland is a site of occurrence of tumors and cysts, and it serves as the biopsy site for the diagnosis of Sjögren syndrome. However, its imaging features have not been well understood. Here we attempted to depict the labial gland by high-resolution MR imaging. MATERIALS AND METHODS The labial glands from 89 patients without Sjögren syndrome, 14 patien...
متن کاملThe Histopathology of Labial Salivary Glands in Primary Sjögren's Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates
Recently, we revealed the importance of follicular helper T cells (T(FH)) in the pathogenesis of primary Sjögren's syndrome (pSS). In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on T(FH) and germinal center B cells. We selected tissue blocks obtained from ten...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2017
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2017.8083